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Related Experiment Videos

Five-year data from the Oxford Laser Prostatectomy Trial.

S R Keoghane1, M E Sullivan, H A Doll

  • 1Department of Urology, Churchill Hospital, and Health Services Research Unit, University of Oxford, Oxford.

BJU International
|August 10, 2000
PubMed
Summary

Five years after prostate surgery, many patients died or became disabled from other medical conditions. Re-operation rates were similar for transurethral resection of the prostate (TURP) and contact laser prostatectomy.

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Area of Science:

  • Urology
  • Surgical Oncology

Background:

  • Benign prostatic hyperplasia (BPH) is a common condition in aging men.
  • Surgical interventions like transurethral resection of the prostate (TURP) and contact laser prostatectomy are standard treatments.
  • Long-term outcomes and natural history following these procedures require further investigation.

Purpose of the Study:

  • To evaluate the long-term natural history of patients undergoing either TURP or contact laser prostatectomy.
  • To compare the outcomes of these two surgical techniques over a 5-year follow-up period.

Main Methods:

  • A prospective, double-blind, randomized controlled trial was conducted.
  • Patients were followed for 5 years post-surgery.
  • Data collection included mortality, re-operation rates, and symptom progression.

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Main Results:

  • At 5 years, 11.5% of patients had died, and 5.4% were too incapacitated by comorbidities to respond.
  • Re-operation rates were comparable: 18% for contact laser prostatectomy and 14.5% for TURP.
  • Two patients in each group required alpha-blockers for symptom recurrence.

Conclusions:

  • A significant proportion of patients experienced mortality or disability due to coexistent medical conditions within 5 years of prostatic surgery.
  • Contact laser prostatectomy and TURP demonstrated similar re-operation rates, suggesting comparable long-term efficacy in this cohort.