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Related Experiment Videos

Hyperhomocysteinemia and thrombosis.

M Makris1

  • 1Division of Molecular and Genetic Medicine, Royal Hallamshire Hospital, Sheffield, UK.

Clinical and Laboratory Haematology
|August 10, 2000
PubMed
Summary

Patients with homocystinuria face higher risks of blood clots. While vitamins can lower homocysteine levels, their impact on the disease

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Area of Science:

  • Cardiovascular Science
  • Metabolic Disorders
  • Hematology

Background:

  • Homocystinuria is linked to elevated homocysteine levels.
  • Elevated homocysteine is a known risk factor for thrombosis.
  • Moderate homocysteine increases correlate with venous and arterial thrombotic events.

Purpose of the Study:

  • To review the association between homocysteine levels and thrombotic risk.
  • To discuss the potential of vitamin therapy to mitigate these risks.

Main Methods:

  • Literature review of studies on homocystinuria and thrombosis.
  • Analysis of the effects of folic acid, vitamin B12, and vitamin B6 on homocysteine levels.

Main Results:

  • Patients with homocystinuria have a significantly increased risk of venous and arterial thrombosis.
  • Moderate elevations in homocysteine are associated with deep vein thrombosis, myocardial infarction, cerebral infarction, and peripheral vascular disease.
  • Vitamin therapy (folic acid, B12, B6) can effectively reduce homocysteine levels.

Conclusions:

  • Elevated homocysteine is a critical risk factor for vascular events in homocystinuria.
  • While vitamin supplementation normalizes homocysteine levels, its effect on altering the disease's natural progression remains unproven.

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