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Related Experiment Videos

Interactions between Streptococcus suis serotype 2 and different epithelial cell lines.

Mélanie Lalonde1, Mariela Segura1, Sonia Lacouture1

  • 1Groupe de Recherche sur les Maladies Infectieuses du Porc, Faculté de médecine vétérinaire, Université de Montréal, CP 5000, Saint-Hyacinthe, Québec, Canada J2S 7C61.

Microbiology (Reading, England)
|August 10, 2000
PubMed
Summary

Streptococcus suis serotype 2 adheres to, but does not invade, epithelial cells. This swine pathogen causes disease through adherence and cell injury, unlike Group B Streptococcus which invades cells.

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Area of Science:

  • Veterinary Microbiology
  • Infectious Diseases
  • Bacterial Pathogenesis

Background:

  • Streptococcus suis serotype 2 is a significant swine pathogen causing various diseases, including meningitis.
  • It is also a zoonotic agent, posing risks to humans in contact with pigs.
  • The pathogenesis and virulence factors of S. suis serotype 2 remain poorly understood.

Purpose of the Study:

  • To investigate the interactions of S. suis serotype 2 with epithelial cells.
  • To compare the pathogenic mechanisms of S. suis serotype 2 with Group B Streptococcus (GBS).
  • To elucidate the role of adherence, invasion, and toxic effects in S. suis serotype 2 infection.

Main Methods:

  • Studied adhesion, invasion, and toxic effects of S. suis serotype 2 on various epithelial cell lines (LLC-PK1, PK(15), A549, HeLa, MDCK).

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  • Compared these interactions with those of Group B Streptococcus (GBS).

    • Main Results:

    • S. suis serotype 2 demonstrated adherence to epithelial cells but lacked invasion capabilities, unlike GBS.
    • Adhesins involved in S. suis serotype 2 adherence are cell wall-associated and partially masked by the capsule.
    • The haemolysin (suilysin) produced by S. suis serotype 2 contributes to observed toxic effects on epithelial cells.

    Conclusions:

    • Pathogenesis of S. suis serotype 2 infection differs significantly from GBS.
    • Suilysin-positive S. suis strains may utilize adherence and cell injury, rather than direct invasion, in the multistep process leading to bacteremia and meningitis.