Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Experiment Videos

Evidence that a decrease in liver glycogen content stimulates FFA mobilization during exercise.

K Couturier1, P Bélanger, M G Latour

  • 1UFR-STAPS, Faculté des Sciences du Sport et de l'Education Physique, Université Claude Bernard, Lyon, France.

Canadian Journal of Applied Physiology = Revue Canadienne De Physiologie Appliquee
|August 10, 2000
PubMed
Summary

Reducing liver glycogen before exercise impacts metabolic responses. This study compared glucagon injection, food restriction, and normal feeding in rats during rest and exercise, revealing distinct metabolic shifts.

Related Concept Videos

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

On the use of a Transformer Neural Network to deconvolve ultrasonic signals.

Ultrasonics·2025
Same author

Canadian Surgery Forum 2018: St. John's, NL Sept. 13-15, 2018.

Canadian journal of surgery. Journal canadien de chirurgie·2022
Same author

Acute emotional stress and high fat/high fructose diet modulate brain oxidative damage through NrF2 and uric acid in rats.

Nutrition research (New York, N.Y.)·2020
Same author

An overview of foodborne outbreaks in Canada reported through Outbreak Summaries: 2008-2014.

Canada communicable disease report = Releve des maladies transmissibles au Canada·2018
Same author

Evaluation of self-swabbing coupled with a telephone health helpline as an adjunct tool for surveillance of influenza viruses in Ontario.

BMC public health·2016
Same author

Loss of ovarian estrogens causes only mild deterioration of glucose homeostasis in female ZDF rats preventable by voluntary running exercise.

Hormone and metabolic research = Hormon- und Stoffwechselforschung = Hormones et metabolisme·2014

Area of Science:

  • Exercise Physiology
  • Metabolic Regulation
  • Biochemistry

Background:

  • Liver glycogen is a critical energy source during prolonged exercise.
  • Understanding how pre-exercise glycogen levels influence metabolic responses is vital for optimizing athletic performance and health.

Purpose of the Study:

  • To investigate the effects of pre-exercise liver glycogen depletion on metabolic responses during exercise.
  • To compare the metabolic impact of glucagon injection versus food restriction in altering liver glycogen levels before exercise.

Main Methods:

  • Rats were divided into three groups: glucagon injection, 50% food restriction (1/2-fast), and normally fed.
  • Metabolic parameters including liver glycogen, plasma insulin, beta-hydroxybutyrate, and free fatty acids (FFA) were measured at rest and during standardized exercise.

Related Experiment Videos

  • Exercise was performed at 26 m/min on a 0% grade treadmill.

    • Main Results:

    • Normally fed rats had significantly higher resting liver glycogen than the other groups.
    • Liver glycogen was significantly reduced in normally fed rats after exercise.
    • Plasma insulin decreased in all groups post-exercise. Beta-hydroxybutyrate levels were similar in glucagon-injected and normally fed rats, but lower in 1/2-fast rats.
    • Free fatty acid (FFA) concentrations increased significantly in all groups during exercise, with no significant difference between glucagon-injected and 1/2-fast rats.

    Conclusions:

    • Pre-exercise liver glycogen reduction, whether induced by glucagon or food restriction, alters metabolic substrate utilization during exercise.
    • Glucagon injection may partially mimic the metabolic effects of moderate food restriction on certain hormonal and substrate responses during exercise.
    • Further research is needed to fully elucidate the distinct roles of different glycogen depletion strategies on exercise metabolism.