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The NOTCH4 locus is associated with susceptibility to schizophrenia
1Institute of Biological Psychiatry, Schizophrenia Association of Great Britain, Bryn Hyfryd, The Crescent, Bangor, Gwynedd, UK. jwei@hgmp.mrc.ac.uk
Nature Genetics
|August 10, 2000
Abstract:
Linkage disequilibrium mapping of the MHC region in 80 British parent-offspring trios showed that NOTCH4 was highly associated with schizophrenia. The A-->G substitution in the promoter region and the (CTG)n repeat in exon 1 of NOTCH4 may be candidate sites conferring susceptibility to schizophrenia.