Related Experiment Video
Updated: Aug 14, 2026

P50 Sensory Gating in Infants
Published on: December 26, 2013
A rice starch added follow-on formula for infants with sleeping difficulty
P Jirapinyo1, N Thammonsiri, R Wongarn
1Department of Pediatrics, Faculty of Medicine Siriraj Hospital, Mahidol University, Bangkok, Thailand.
Insights
Adding rice starch to follow-on formula improved nighttime sleep for most infants. This study found 73.3% of infants experienced satisfactory sleep results with the modified formula.
Area of Science:
- Pediatrics
- Infant Nutrition
- Sleep Medicine
Background:
- Infant sleeping difficulty is a common concern for parents.
- Cow's milk-based follow-on formulas are widely used for infants.
- Modifications to infant formula may impact sleep patterns.
Purpose of the Study:
- To evaluate the efficacy of a cow's milk-based follow-on formula with added rice starch in improving infant nighttime sleep.
- To assess the safety and tolerability of the test formula.
Main Methods:
- A study enrolled 15 infants aged 4-12 months with sleeping difficulties.
- Participants consumed a test formula with added rice starch nightly for 7 days.
- Infant sleep patterns were monitored for 2 days prior and during the 7-day study period.
Main Results:
- 73.3% (11 out of 15) of infants showed satisfactory improvements in nighttime sleep.
- Two infants (13.3%) were withdrawn due to vomiting, which coincided with respiratory tract infections.
- Two infants (13.3%) were lost to follow-up.
Conclusions:
- The majority of infants experienced satisfactory sleep pattern improvements with the rice starch-added follow-on formula.
- The test formula demonstrated potential benefits for infant sleep, though further safety monitoring is advised.
- Rice starch addition to follow-on formula is a viable option for addressing infant sleep disturbances.
Abstract:
A total of 15 infants aged between 4-12 months with sleeping difficulty were enrolled in the study. All participants were given a test follow-on formula (cow's milk based), with added rice starch. The test formula was advised to be given at night-time for a 7-day period. Sleeping patterns were recorded 2 days prior to the study and during the 7-day study period. It was shown than 11 out of 15 cases (73.3%) had satisfactory results. Two cases (13.3%) were withdrawn from the study by their parents due to vomiting after taking the formula. We found that both cases developed concomitant respiratory tract infection one day after starting the study, and 2 cases (13.3%) were lost to follow-up. In conclusion, the majority of cases showed satisfactory results in terms of night sleeping pattern after switching to the rice starch added follow--on formula.
Related Concept Videos
Sleep-Wake Cycles
NREM Sleep
NREM sleep comprises four progressive stages that seamlessly merge:
Drugs for Treatment of Constipation-Predominant IBS
Enteral Nutrition II: Nasointestinal and Gastrostomy Feeding
Nasointestinal Feeding
Nasointestinal feeding involves placing a tube through...
Stages of Sleep
Before sleep begins, in wakefulness, the brain exhibits primarily beta waves, which are high in frequency and low in amplitude, indicating alertness...

