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["Critical-illness" polyneuropathy and -myopathy].

F S Leijten1, M A de Letter, A A Op de Coul

  • 1Afd. Klinische Neurofysiologie, Universitair Medisch Centrum Utrecht.

Nederlands Tijdschrift Voor Geneeskunde
|August 10, 2000
PubMed
Summary

Critical-illness polyneuropathy and myopathy (CIPNM) is a common cause of ICU weakness, affecting 35-80% of ventilated patients. Diagnosis requires electrophysiology or biopsy, and recovery can be lengthy.

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Critical illness polyneuropathy and myopathy (CIPNM): evidence for local immune activation by cytokine-expression in the muscle tissue.

Journal of neuroimmunology·2000

Area of Science:

  • Neurology
  • Intensive Care Medicine
  • Pathology

Context:

  • Critical-illness polyneuropathy and myopathy (CIPNM) is the most frequent cause of muscle weakness in intensive care units (ICUs).
  • CIPNM affects 35-80% of patients requiring prolonged mechanical ventilation.
  • It is linked to the broader syndrome of multiple organ dysfunction.

Purpose:

  • To outline the characteristics, diagnosis, and implications of critical-illness polyneuropathy and myopathy.
  • To highlight the association between CIPNM, critical illness, and specific treatments like corticosteroids.
  • To describe the challenges in patient recovery, including ventilation weaning and rehabilitation.

Summary:

  • CIPNM involves immune responses, increased vascular permeability, and inflammation, leading to muscle damage.
  • Electrophysiological studies and muscle biopsies are often needed for diagnosis.
  • Corticosteroid use is a notable factor associated with myopathy.

Impact:

  • Understanding CIPNM is crucial for managing critically ill patients and improving outcomes.
  • Difficulties in weaning from mechanical ventilation and prolonged rehabilitation are common.
  • Early recognition and management strategies may improve patient recovery trajectories.

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