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Published on: January 13, 2017
Antibiotic 26-deoxylaidlomycin isolated from Streptomyces sp. Ar386 from Brazilian soil
K Ujikawa1, W Vilegas, J H Vilegas
1Faculdade de Ciências Farmacêuticas da Universidade Estadual Paulista Júlio de Mesquita Filho-UNESP, Araraquara, SP, Brazil.
Abstract:
An actinomycete strain (Ar386) was isolated from the soil of the Araraquara region, SP, Brazil. The strain, named Streptomyces jacareensis, formed irregular rayed, rugose, grayish-white mycelium with sinuous, branched hyphae carrying rare isolated spores; assimilated glucose, galactose, inositol, ribose, maltose, sucrose, melibiose and starch but not mannitol, rhamnose, arabinose, xylose, lactose and raffinose; and contained LL-diaminopimelic acid in its cell wall. An antibiotic active against Gram-positive bacteria, which was characterized as being 26-deoxylaidlomycin and which may have application against poultry coccidiosis, was isolated from cultures of the strain. This was the first isolation of this antibiotic from a microorganism of the genus Streptomyces and also the first isolation of this antibiotic in Brazil.
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