Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Experiment Videos

[Bacterial systems for expelling toxic metals].

E Vargas1, A H Alvarez, C Cervantes

  • 1Instituto de Investigaciones Químico-Biológicas Universidad Michoacana, Morelia, Mich., México. Cvega@zeuz.ccu.umich.mx

Revista Latinoamericana De Microbiologia
|August 10, 2000
PubMed
Summary

Bacteria utilize diverse strategies to resist toxic metals, including efflux systems. Recent molecular analyses reveal two primary mechanisms: P-type ATPases and proton antiporter systems for metal ion extrusion.

Related Concept Videos

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Assessing endometrial microbiota in endometriosis: culturomics and sequencing analysis of receptive-phase tissue.

Current research in microbial sciences·2026
Same author

Sentinel Lymph Node Biopsy in Elderly Melanoma Patients: A Real Practice Cohort.

Actas dermo-sifiliograficas·2023
Same author

Sentinel Lymph Node Biopsy in Elderly Melanoma Patients: A Real Practice Cohort.

Actas dermo-sifiliograficas·2023
Same author

The mid-secretory endometrial transcriptomic landscape in endometriosis: a meta-analysis.

Human reproduction open·2022
Same author

High-yield production of major T-cell ESAT6-CFP10 fusion antigen of M. tuberculosis complex employing codon-optimized synthetic gene.

International journal of biological macromolecules·2021
Same author

Parental ancestry and risk of early pregnancy loss at high altitude.

FASEB journal : official publication of the Federation of American Societies for Experimental Biology·2020

Area of Science:

  • Environmental microbiology
  • Biochemistry
  • Molecular biology

Context:

  • Bacteria encounter diverse toxic metals in their environment.
  • Metal resistance mechanisms are crucial for bacterial survival and adaptation.
  • These mechanisms involve various strategies like precipitation, sequestration, and efflux systems.

Purpose:

  • To elucidate the molecular mechanisms of bacterial toxic metal resistance.
  • To understand how bacteria maintain metal homeostasis for essential micronutrients and extrude non-essential toxic metals.
  • To detail the biochemical processes underlying metal ion efflux.

Summary:

  • Bacteria have evolved multiple resistance strategies against toxic metals, including extracellular precipitation, cell envelope sequestration, intracellular accumulation, redox transformations, and membrane efflux systems.
  • Genes conferring metal tolerance can be located on chromosomes or plasmids.
  • Two main efflux mechanisms have been identified: P-type ATPases and proton antiporter systems, which are vital for extruding toxic metal cations such as copper, cadmium, zinc, nickel, cobalt, and silver.

Impact:

  • Provides a molecular-level understanding of bacterial heavy metal resistance.
  • Highlights the importance of efflux systems in maintaining metal homeostasis.
  • Informs potential strategies for bioremediation and combating antibiotic resistance, as metal resistance genes often co-localize with antibiotic resistance genes.

Related Experiment Videos