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Bactericidal effect of extracorporeal shock waves on Staphylococcus aureus
C VON Eiff, J Overbeck1, G Haupt1
1Institute of Medical Microbiology, *Department of Trauma- and Hand-Surgery, †Central Animal Experimentation Facility, ‡Department of General Surgery - Surgical Research, Westfälische Wilhelms-Universität Münster, 48149 Münster and §Department of Urology, Ruhr-Universität Bochum, 44627 Herne, Germany.
Journal of Medical Microbiology
|August 10, 2000
Summary
Extracorporeal shock waves show significant bactericidal effects against Staphylococcus aureus in vitro. Higher impulse rates are crucial for effective bacterial reduction, suggesting potential for new infection therapies.
Area of Science:
- Microbiology
- Biophysics
- Medical Technology
Background:
- Limited understanding of shock wave effects on prokaryotes.
- Established knowledge on shock waves impacting eukaryotic tissues.
Purpose of the Study:
- To investigate the in vitro bactericidal effects of extracorporeal shock waves on Staphylococcus aureus.
- To determine the efficacy of shock waves against bacterial microorganisms.
Main Methods:
- In vitro exposure of Staphylococcus aureus suspensions to extracorporeal shock waves.
- Utilized standard energy levels for calculus disintegration.
- Assessed bacterial viability through colony-forming units (cfu) counts.
Main Results:
- A mean decrease of 3.1 log(10) in Staphylococcus aureus cfu/ml was observed.
- Impulse rates of ≥350 significantly reduced bacterial counts to detection limits.
- Lower impulse rates showed minimal bactericidal effect.
Conclusions:
- Extracorporeal shock waves exhibit a notable bactericidal effect on Staphylococcus aureus.
- Therapeutic strategies for bacterial infections could potentially leverage this shock wave effect.
- Further research is warranted to explore clinical applications.