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Related Experiment Videos

Cardiac abnormalities in type 1 diabetes.

G de Simone1, G F Mureddu, O Vaccaro

  • 1Department of Clinical and Experimental Medicine, Federico II, University Hospital School of Medicine, Naples, Italy. simogi@unina.it

Italian Heart Journal : Official Journal of the Italian Federation of Cardiology
|August 10, 2000
PubMed
Summary
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Type 1 diabetes in normotensive adults leads to increased left ventricular (LV) mass and supernormal systolic function. However, diastolic function shows impaired relaxation despite normal chamber stiffness.

Area of Science:

  • Cardiology
  • Diabetology
  • Medical Imaging

Background:

  • Type 1 diabetes mellitus (T1DM) can affect cardiovascular health.
  • Left ventricular (LV) structural and hemodynamic changes in T1DM are not fully understood.

Purpose of the Study:

  • To evaluate LV geometry, systolic, and diastolic function in patients with T1DM.
  • To compare these parameters with age- and sex-matched healthy controls.

Main Methods:

  • Doppler echocardiography was performed in 40 normotensive T1DM patients and 40 controls.
  • Patients had no coronary heart disease or valvular lesions.
  • A case-control design was employed.

Main Results:

  • T1DM patients showed increased LV mass and dimension but normal relative wall thickness.

Related Experiment Videos

  • LV ejection fraction and midwall shortening were supernormal in T1DM patients.
  • Diastolic function revealed prolonged isovolumic relaxation time and impaired active relaxation, despite normal chamber stiffness.

    • Conclusions:

    • Normotensive T1DM patients exhibit moderate LV mass increase and supernormal systolic function.
    • LV active relaxation is impaired, but chamber stiffness remains normal.
    • These findings are independent of disease duration, glycosylated hemoglobin, or target organ damage.