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Light chain deposition disease neuropathy resembling amyloid neuropathy in a multiple myeloma patient
M P Grassi1, F Clerici, C Perin
1Department of Neurology, L. Sacco Hospital, Milan, Italy.
Italian Journal of Neurological Sciences
|August 10, 2000
Abstract:
A 65-year-old man with IgG lambda multiple myeloma developed severe polyneuropathy with prominent thermal-pain sensory impairment and autonomic failure. Although the clinical presentation suggested amyloid neuropathy, nerve biopsy showed the immunohistochemical and ultrastructural features typical of light chain deposition disease (LCDD). A precise morphologic and clinical description of LCDD neuropathy is given for the first time in the present report.