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Optimised extraction of folic acid from multivitamin-mineral preparations for liquid chromatographic analysis
M A Kall1, P Nørgaard, S J Pedersen
1Danish Veterinary and Food Administration, Institute of Food Research and Nutrition, Ministry of Food, Agriculture and Fisheries, Søborg. mak@fdir.dk
Abstract:
Degradation of folic acid may occur during extraction of multivitamin-mineral preparations. The degradation may be caused by presence of ions such as Fe3+ and Cu2+, however, the buffer composition may also be critical. This study presents an optimised extraction procedure tested on 24 different products of multivitamin-mineral tablets. The present method yielded mean recoveries of 97% (n = 20) for folic acid and prevented degradation of folic acid in at least 24 h in extracts from multivitamin-mineral tablets.
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