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Poly(vinyl chloride) ion-selective electrodes for piribedil determination
Y M Issa1, M M Hassouna, F M Abdel-Gawad
1Faculty of Science, Cairo University, Giza, Egypt.
Journal of Pharmaceutical and Biomedical Analysis
|August 10, 2000
Summary
New ion-selective electrodes for piribedil (PD) offer accurate and selective detection in various samples. These electrodes provide a reliable method for quantifying PD in pharmaceutical and biological applications.
Area of Science:
- Analytical Chemistry
- Electrochemistry
- Materials Science
Background:
- Piribedil (PD) is a medication used for various neurological conditions.
- Accurate quantification of PD is crucial for therapeutic monitoring and pharmaceutical quality control.
- Existing methods for PD determination may lack selectivity or require complex sample preparation.
Purpose of the Study:
- To develop and characterize novel ion-selective electrodes (ISEs) for the determination of piribedil (PD).
- To evaluate the performance of PD-ISEs in terms of linearity, working range, pH stability, and selectivity.
- To assess the applicability of the developed electrodes for PD quantification in real-world samples such as pharmaceutical formulations and biological fluids.
Main Methods:
- Construction of PVC matrix membrane ISEs incorporating piribedil-tetraphenylborate (PD-TPB) as the electroactive material.
- Optimization of plasticizing solvent mediators (dibutylphthalate or dioctylphthalate).
- Potentiometric measurements to determine linearity, working pH range, and isothermal coefficients.
- Evaluation of electrode selectivity against common inorganic cations and organic substances.
- Application of ISEs for PD determination using standard addition and potentiometric titration methods.
Main Results:
- The developed PD-ISEs exhibited a linear potentiometric response over a wide concentration range (e.g., 8.0 x 10(-6) to 10(-2) M PD).
- The electrode based on dioctylphthalate demonstrated optimal performance with a Nernstain slope of 30 mV/decade.
- The electrodes showed excellent selectivity for PD in the presence of potential interfering substances found in biological fluids.
- The ISEs maintained stability and functionality after prolonged immersion in distilled water (over 5 months).
Conclusions:
- Novel piribedil ion-selective electrodes have been successfully developed using a PVC matrix membrane.
- The optimized electrodes provide a sensitive, selective, and stable potentiometric method for piribedil determination.
- These electrodes are suitable for the accurate quantification of piribedil in pure solutions, pharmaceutical tablets, and biological fluids.