Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Experiment Videos

Integrated sample collection and handling for drug discovery bioanalysis.

N Zhang1, K Rogers, K Gajda

  • 1Department of Pharmacokinetics, Dynamics and Metabolism, Parke-Davis Pharmaceutical Research, Division of Warner-Lambert, Ann Arbor, MI 48105, USA.

Journal of Pharmaceutical and Biomedical Analysis
|August 10, 2000
PubMed
Summary

A new integrated sample handling process streamlines drug discovery bioanalysis, improving efficiency and automation. This method maintains precision and accuracy comparable to conventional approaches for drug development.

Related Concept Videos

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Sparse interleaved sampling for high resolution focal construct geometry X-ray tomography.

Optics express·2023
Same author

Organic synthesis associated with serpentinization and carbonation on early Mars.

Science (New York, N.Y.)·2022
Same author

Coastal flood risk within a peri-urban area: Sussex Inlet district, SE Australia.

Natural hazards (Dordrecht, Netherlands)·2021
Same author

Mangrove sinkholes (<i>cenotes</i>) of the Yucatan Peninsula, a global hotspot of carbon sequestration.

Biology letters·2021
Same author

Thresholds of mangrove survival under rapid sea level rise.

Science (New York, N.Y.)·2020
Same author

Organic synthesis on Mars by electrochemical reduction of CO<sub>2</sub>.

Science advances·2018

Area of Science:

  • Pharmacology
  • Analytical Chemistry
  • Biotechnology

Background:

  • Traditional bioanalytical sample handling in drug discovery is often time-consuming and labor-intensive.
  • Streamlining sample processing is crucial for accelerating drug development timelines.
  • Automation and integration in sample handling can significantly enhance laboratory efficiency.

Purpose of the Study:

  • To describe an integrated sample handling process for drug discovery bioanalysis.
  • To demonstrate the streamlining of study design, sample collection, and automated bioanalytical sample processing.
  • To evaluate the efficiency, automation, and integration capabilities of the new process.

Main Methods:

  • Development of a comprehensive sample handling protocol including a sample collection map and formatting guidelines.

Related Experiment Videos

  • Implementation of dilution schemes for high-concentration samples and selection of appropriate biological fluids.
  • Evaluation of two automated liquid-handling workstations for sample processing.
  • Comparison of the new integrated process with conventional sample handling methods.

    • Main Results:

    • The integrated sample handling process demonstrated comparable precision and accuracy to conventional methods.
    • Pharmacokinetic profiles and parameters obtained using the new process were consistent with traditional approaches.
    • Significant improvements in the efficiency of drug discovery bioanalysis were achieved.
    • Successful integration of pre-clinical protocol design, sample collection, and bioanalysis processes was realized.

    Conclusions:

    • The described integrated sample handling process significantly enhances the efficiency of drug discovery bioanalysis.
    • The new approach offers comparable analytical performance to conventional methods while improving automation and integration.
    • This streamlined process facilitates the integration of study design, sample collection, and bioanalysis, accelerating drug development.