Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Experiment Videos

Hyaline membrane disease.

P M Farrell, M E Avery

    The American Review of Respiratory Disease
    |May 1, 1975
    PubMed
    Summary
    This summary is machine-generated.

    Hyaline membrane disease is caused by a pulmonary surfactant deficiency. Prenatal diagnosis and treatments like continuous distending airway pressure and glucocorticoids improve outcomes.

    Related Concept Videos

    You might also read

    Related Articles

    Articles linked to this work by shared authors, journal, and citation graph.

    Sort by
    Same author

    ECFS standards of care on CFTR-related disorders: Towards a comprehensive program for affected individuals.

    Journal of cystic fibrosis : official journal of the European Cystic Fibrosis Society·2024
    Same author

    Inconclusive diagnosis after a positive newborn bloodspot screening result for cystic fibrosis; clarification of the harmonised international definition.

    Journal of cystic fibrosis : official journal of the European Cystic Fibrosis Society·2019
    Same author

    Vitamin C in premature and full-term human neonates.

    Redox report : communications in free radical research·2016
    Same author

    Refining the continuum of CFTR-associated disorders in the era of newborn screening.

    Clinical genetics·2015
    Same author

    Improving the time efficiency of the Fourier synthesis method for slice selection in magnetic resonance imaging.

    Physica medica : PM : an international journal devoted to the applications of physics to medicine and biology : official journal of the Italian Association of Biomedical Physics (AIFB)·2015
    Same author

    Nursing care of the domiciliary patient in queensland.

    The Australian journal of physiotherapy·2014
    Same journal

    Human lung lysozyme: sources and properties.

    The American review of respiratory disease·2015
    Same journal

    "Immotile-cilia" syndrome and ciliary abnormalities induced by infection and injury.

    The American review of respiratory disease·2013
    Same journal

    Adult criteria for obstructive apnea do not identify children with serious obstruction.

    The American review of respiratory disease·1993
    Same journal

    Cell adhesion molecules and the bronchial epithelium.

    The American review of respiratory disease·1993
    Same journal

    Adhesion molecules and cytokine production.

    The American review of respiratory disease·1993
    Same journal

    Molecular mechanisms mediating lymphocyte recirculation, inflammation, and metastasis formation.

    The American review of respiratory disease·1993
    See all related articles

    Area of Science:

    • Neonatal Medicine
    • Pulmonary Biology
    • Obstetrics

    Background:

    • Hyaline membrane disease (HMD) is a significant cause of neonatal respiratory distress.
    • Epidemiologic studies have consistently linked HMD to specific risk factors.
    • Recent years have seen substantial progress in understanding and managing HMD.

    Purpose of the Study:

    • To review recent advances in the diagnosis and treatment of hyaline membrane disease.
    • To highlight the central role of pulmonary surfactant deficiency in HMD pathogenesis.
    • To discuss current therapeutic strategies aimed at preventing or treating HMD.

    Main Methods:

    • Prenatal diagnosis using amniocentesis to analyze lecithin-to-sphingomyelin ratio or surfactant titer (shake test).
    • Epidemiologic data confirmation and review of clinical evidence supporting surfactant deficiency hypothesis.

    Related Experiment Videos

  • Evaluation of management strategies including continuous distending airway pressure and antenatal glucocorticoid administration.

    • Main Results:

    • Prenatal diagnostic tests reliably predict the risk of HMD.
    • Strong evidence supports pulmonary surfactant deficiency as the primary cause of HMD.
    • Management strategies focus on increasing end-expiratory lung volume and accelerating fetal lung maturation.

    Conclusions:

    • Hyaline membrane disease is fundamentally a disorder of insufficient pulmonary surfactant.
    • Prenatal assessment and interventions significantly improve the management of HMD.
    • Therapeutic approaches targeting surfactant levels and lung function are effective.