Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Experiment Videos

Biliary tract brush cytology.

M S Vadmal1, S Byrne-Semmelmeier, T F Smilari

  • 1Department of Pathology, North Shore University Hospital, Manhasset, New York 11030, USA.

Acta Cytologica
|August 10, 2000
PubMed
Summary
This summary is machine-generated.

Related Concept Videos

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Acquired reactive perforating collagenosis associated with papillary thyroid carcinoma: a paraneoplastic phenomenon?

Clinical and experimental dermatology·2009
Same author

Aspergillus fumigatus Majocchi's granuloma in a patient with acquired immunodeficiency syndrome.

Clinical and experimental dermatology·2008
Same author

Botryomycosis caused by Staphylococcus aureus and Pneumocystis carinii in a patient with acquired immunodeficiency disease.

Clinical and experimental dermatology·2008
Same author

Gene expression patterns of paired bronchioloalveolar carcinoma and benign lung tissue.

Annals of clinical and laboratory science·2001
Same author

Liposarcoma in the bone marrow: a terminal event.

Annals of clinical and laboratory science·2001
Same author

Ultrastructure of the periductal area of comedo carcinoma in situ of the breast.

Annals of clinical and laboratory science·2001
Same journal

Predictive Immunohistochemical Biomarkers for Antibody-Drug Conjugate Therapy in Pulmonary Cytology.

Acta cytologica·2026
Same journal

The Development Path of Gynecological Cytology after Papanicolaou: from Bethesda to Artificial Intelligence and Personalized Medicine.

Acta cytologica·2026
Same journal

Cytological Features of CIC-rearranged Sarcoma. A Report of 5 New Cases and Review of the Literature.

Acta cytologica·2026
Same journal

Pericardial Fluid Metastatic Tumor Distribution and Fluid Volume Analysis, a 10-Year Institutional Experience.

Acta cytologica·2026
Same journal

The cytopathology of infectious disease: A review.

Acta cytologica·2026
Same journal

Investigation of a storage method for peritoneal and pleural effusion cytology specimens for long-term preservation of antigenicity in immunocytochemical staining.

Acta cytologica·2026
See all related articles

Endoscopic retrograde cholangiopancreatography (ERCP) brush cytology is a safe method for diagnosing biliary tree lesions. Small, 3D cell clusters with atypia in ERCP smears strongly indicate malignancy.

Area of Science:

  • Gastroenterology
  • Cytopathology
  • Oncology

Background:

  • Biliary tree lesions require accurate diagnosis.
  • Endoscopic retrograde cholangiopancreatography (ERCP) is a common diagnostic tool.

Purpose of the Study:

  • To prospectively review biliary brush smears obtained during ERCP.
  • To identify cytologic features indicative of malignancy in biliary lesions.

Main Methods:

  • 175 specimens from 147 patients were analyzed.
  • Papanicolaou staining was used for cytologic analysis.
  • Smears were categorized into benign/reactive, significant atypia, and suspicious/positive.

Main Results:

  • Suspicious/positive smears consistently showed tightly cohesive, small, 3D cell clusters.

Related Experiment Videos

  • These clusters exhibited features of malignant cells.
  • Benign/reactive and significant atypia categories were also defined.

    • Conclusions:

    • ERCP-guided brushing is a safe and effective diagnostic procedure for biliary tree lesions.
    • Small, 3D epithelial clusters with marked atypia are significant indicators of malignancy.
    • Specific features like single cells, vacuoles, or nucleoli are not essential for diagnosing malignancy.