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Updated: Aug 17, 2026

Assessing Changes in Volatile General Anesthetic Sensitivity of Mice after Local or Systemic Pharmacological Intervention
Published on: October 16, 2013
The pharmacology of anesthetic drugs in elderly patients
1Palo Alto VA Health Care System, California, USA.
Abstract:
Elderly patients are more sensitive to anesthetic drugs than younger patients. This increased sensitivity has a pharmacokinetic basis if the dose produces a higher drug concentration in an elderly patient than in a younger patient. The increased sensitivity has a pharmacodynamic basis if the same concentration produces a more profound drug effect in elderly patients. This article reviews the mechanisms of increased sensitivity of elderly patients to opioids, hypnotics, amnestica, and muscle relaxants.
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