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Meningioangiomatosis with a predominant fibrocalcifying component

E Izycka-Swieszewska1, R Rzepko, S Kopczynski

  • 1Department of Pathomorphology, Medical University of Gdansk, Poland. astwadur@friko6.onet.pl

Neuropathology : Official Journal of the Japanese Society of Neuropathology
|August 10, 2000
PubMed

Insights

Meningioangiomatosis, a rare brain lesion, was resected from a 31-year-old female. The study highlights pathological microvessels and spindle cell proliferation, suggesting a role for angiogenesis in its development.

Area of Science:

  • Neuropathology
  • Neuro-oncology
  • Vascular Biology

Background:

  • Meningioangiomatosis is a rare, benign brain tumor characterized by proliferation of meningothelial and vascular elements.
  • Understanding its pathogenesis is crucial for diagnosis and management.

Observation:

  • A case of meningioangiomatosis from the parietal lobe of a 31-year-old female is presented.
  • Macroscopic examination revealed calcified nodules within hardened tissue.
  • Histological analysis showed calcified masses with spindle/oval cells, pathological microvessels, and perivascular proliferation.

Findings:

  • Immunohistochemistry identified spindle cells positive for vimentin and epithelial membrane antigen.
  • Gliosis with Rosenthal fibers and connective tissue elements were noted.
  • The findings suggest a significant role for angiogenesis in meningioangiomatosis.

Implications:

  • This case contributes to the understanding of meningioangiomatosis pathogenesis.
  • The role of angiogenesis in this lesion is emphasized.
  • Further research may elucidate targeted therapeutic strategies.

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