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Future devices and directions.

R E Clark1, Z Zafirelis

  • 1Allegheny General Hospital, Pittsburgh, PA, USA.

Progress in Cardiovascular Diseases
|August 10, 2000
PubMed
Summary
This summary is machine-generated.

This review covers 17 left ventricular assist devices (LVADs) in development for heart failure, detailing designs for destination therapy, bridge to transplant, and bridge to recovery. Future LVADs need simplicity, safety, and low cost for clinical and market success.

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Area of Science:

  • Biomedical Engineering
  • Cardiovascular Research
  • Medical Device Development

Background:

  • Left ventricular assist devices (LVADs) are crucial for managing advanced heart failure.
  • Current LVAD technology is progressing through various development stages, including bench testing, animal studies, and early clinical trials.

Purpose of the Study:

  • To summarize the current status and design features of 17 LVADs.
  • To categorize LVADs based on their intended use: destination therapy, bridge to transplant, and bridge to recovery.
  • To identify key design characteristics essential for future LVAD success.

Main Methods:

  • Review of 17 LVADs in development.
  • Categorization based on indications for use.
  • Description of major design features and estimated costs.

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Main Results:

  • Devices are categorized into destination therapy (e.g., aortic sleeved piston pump, magnetically suspended centrifugal pump), bridge to transplant (8 centrifugal, 4 axial flow pumps), and bridge to recovery (external cup, low-cost centrifugal pump).
  • Specific examples of innovative designs are highlighted within each category.

Conclusions:

  • Future LVAD development must prioritize simplicity, safety, low-power requirements, and cost-effectiveness.
  • These features are critical for successful clinical adoption and market viability of new LVADs.