Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Experiment Videos

PPARgamma: observations in the hematopoietic system.

M E Greene1, J Pitts, M A McCarville

  • 1Department of Cancer Biology/Pathology, Children's Memorial Institute for Education and Research (CMIER), Chicago, IL 60614, USA. mgreene@nwu.edu

Prostaglandins & Other Lipid Mediators
|August 11, 2000
PubMed
Summary

Peroxisome Proliferator-Activated Receptor gamma (PPARgamma) is involved in immune responses and hematopoiesis. This study investigates its role in immune cell energy metabolism and function.

Related Concept Videos

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Vertical heterostructure of graphite-MoS<sub>2</sub> for gas sensing.

Nanoscale horizons·2024
Same author

Performance of the new biological small- and wide-angle X-ray scattering beamline 13A at the Taiwan Photon Source.

Journal of applied crystallography·2022
Same author

2021 Canadian Surgery Forum: Virtual, online Sept. 21-24, 2021.

Canadian journal of surgery. Journal canadien de chirurgie·2022
Same author

Correlation between biochemical features and outcomes of preoperative imaging (SPECT-CT and Ultrasound) in primary hyperparathyroidism.

Acta endocrinologica (Bucharest, Romania : 2005)·2022
Same author

Consumer trait responses track change in resource supply along replicated thermal gradients.

Proceedings. Biological sciences·2021
Same author

Development and internal validation of clinical prediction models for outcomes of complicated intra-abdominal infection.

The British journal of surgery·2021

Area of Science:

  • Hematology
  • Immunology
  • Molecular Biology

Background:

  • Peroxisome Proliferator-Activated Receptor gamma (PPARgamma) is a ligand-activated transcription factor.
  • PPARgamma ligands include fatty acids and prostaglandins.
  • Immune cells like lymphocytes and monocytes utilize fatty acids for energy.

Purpose of the Study:

  • To investigate the role of PPARgamma in hematopoiesis and the immune system.
  • To understand PPARgamma gene regulation in blood and immune system development.
  • To build a database for PPARgamma function in hematopoietic and immune cells.

Main Methods:

  • Literature review on PPARgamma function.
  • Expression survey of PPARgamma in hematopoietic and immune system cells.

Related Experiment Videos

  • Analysis of PPARgamma interactions with retinoid biology and immune signaling pathways.

    • Main Results:

    • PPARgamma is expressed in various hematopoietic progenitors, immune cells (T and B lymphocytes, monocytes, macrophages), stromal cells, and endothelial cells.
    • Expression is observed in early embryonic development (xenopus, murine) and fetal liver.
    • PPARgamma opposes TNFalpha and downregulates cytokine production in monocytes.

    Conclusions:

    • PPARgamma appears to play a role in immune responses.
    • It may be involved in regulating energy states during immune cell activation and development.
    • PPARgamma has immunologically relevant effects on erythroid, myeloid, monocytic, lymphocytic, stromal, and endothelial cell function.