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Tracing the evolution of vertebrate fibrillar collagens from an ancestral alpha chain
J Exposito1, C Cluzel, C Lethias
1Institut de Biologie et Chimie des Protéines, CNRS, Unité Propre de Recherche 412, Université Claude Bernard, 7 passage du Vercors, 69367 cedex 07, Lyon, France. jy.exposito@ibcp.fr
Abstract:
From considerations of gene structure, phylogenetic analysis, modular organisation of related proteins and fibril shapes, we suggest a model for the evolution of contemporary vertebrate fibrillar collagens from a common ancestral alpha chain.