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Methods for the Discovery of Novel Compounds Modulating a Gamma-Aminobutyric Acid Receptor Type A Neurotransmission
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The alpha and gamma subunit-dependent effects of local anesthetics on recombinant GABA(A) receptors

M Sugimoto1, I Uchida, S Fukami

  • 1Department of Anesthesiology, Osaka University Medical School, 2-2, Yamadao-ka, Suita, 565-0871, Osaka, Japan. iuchida@anes.med.osaka-u.ac.jp

European Journal of Pharmacology
|August 11, 2000
PubMed

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Ligand-gated ion channels are transmembrane proteins that play a vital role in intercellular communication and functions of the nervous system. They allow the influx of ions across the membrane once the neurotransmitter binds, allowing the subsequent transmission of electrical excitation across the neurons. Other ligand-gated ion channels, like the γ-aminobutyric acid (GABA) receptor, permit anions like chloride into the cells on the binding of the GABA molecule. Their entry into the cell...
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