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Antifilarial activity of some 2H-1-benzopyran-2-ones (coumarins)
R P Tripathi1, R Tripathi, A P Bhaduri
1Division of Medicinal Chemistry, Central Drug Research Institute, Lucknow, India.
Acta Tropica
|August 11, 2000
Abstract:
Six synthetic 2H-1-benzopyran-2-one (cournarin) derivatives (CDRI compounds # 1, 2, 3, 4, 5 and 6) were evaluated for filaricidal activity against Litomosoides carinii and Acanthocheilonema viteae infections in cotton rats (Sigmodon hispidus) and Mastomys coucha respectively. Significant effects on macrofilariae (>80% death/sterilisation) were detected with compounds #2, 3 and 6 against L. carinii and/or A. viteae. Thus detection of filaricidal activity in benzopyrones, which are so far known for anti-inflammatory activity, provides a new lead for development of better filaricidal agents for combating filariasis.