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Occurrence of an aortic arch anomaly in two siblings born to a diabetic mother

K Tokel1, G Yilmaz, B Gürakan

  • 1Department of Pediatrics, Başkent University Faculty of Medicine, Ankara, Turkey.

The Turkish Journal of Pediatrics
|August 11, 2000
PubMed

Insights

A male infant with interruption of aortic arch type A, born to a mother with insulin-dependent diabetes mellitus, died shortly after birth. This rare congenital heart defect has not been previously reported in infants of diabetic mothers.

Area of Science:

  • Cardiology
  • Neonatal Medicine
  • Medical Genetics

Background:

  • Congenital heart defects (CHDs) are a significant concern in infants born to mothers with diabetes mellitus.
  • Maternal diabetes is a known risk factor for various CHDs, but specific associations require further investigation.
  • Interruption of aortic arch (IAA) is a severe CHD requiring prompt diagnosis and management.

Observation:

  • A case report of a male infant with interruption of aortic arch type A is presented.
  • The infant was born to a mother with a 10-year history of insulin-dependent diabetes mellitus.
  • The infant experienced cardiogenic shock and died on the third day of life.

Findings:

  • This case represents the first documented instance of interruption of aortic arch type A in an infant of a diabetic mother.
  • The infant also had a sibling with coarctation of the aorta, suggesting a potential genetic predisposition or shared environmental factors.
  • The presentation highlights the critical impact of maternal diabetes on fetal cardiovascular development.

Implications:

  • This case underscores the importance of screening and monitoring for severe CHDs in infants born to diabetic mothers.
  • Further research is needed to elucidate the specific mechanisms linking maternal diabetes to IAA and other aortic arch anomalies.
  • Early identification and intervention strategies may improve outcomes for infants with similar conditions.

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