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Does resveratrol induce pharmacological preconditioning?

S Bradamante¹, F Piccinini, L Barenghi

¹CNR, University of Milan, Italy.

International Journal of Tissue Reactions

|August 11, 2000

Summary

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Resveratrol protects the heart from damage during ischemia and reperfusion. This cardioprotection is linked to increased adenosine levels, similar to ischemic preconditioning.

Area of Science:

Cardiology
Biochemistry
Pharmacology

Background:

Resveratrol, found in grapes, has antioxidant properties.
Its direct effects on the heart (myocardium) are not well understood.
Investigating resveratrol's potential to reduce heart damage from ischemia and reperfusion.

Purpose of the Study:

To determine if resveratrol administration before ischemia can lessen damage.
To examine resveratrol's impact on high-energy phosphate metabolism and heart contractility.

Main Methods:

Isolated Langendorff perfused rat hearts were used.
Hearts underwent 20 minutes of no-flow ischemia followed by 30 minutes of reperfusion.
31P-nuclear magnetic resonance (NMR) assessed high-energy phosphate metabolism.

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Main Results:

Resveratrol infusion (10 microM) decreased basal phosphorylation potential by 40% without affecting contractility.
Effluent adenosine levels increased by 68%, with a 50% rise in coronary flow.
Postischemic recovery of the rate-pressure product significantly improved (62% vs. 23% in controls).

Conclusions:

Resveratrol administration before ischemia attenuates myocardial damage.
Increased adenosine availability appears to mediate resveratrol's cardioprotective effects.
The metabolic changes resemble those of ischemic preconditioning.