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A cholecystokinin receptor antagonist blocks milk-induced but not maternal-contact-induced decrease of ultrasonic

A Weller1, I H Gispan

  • 1Department of Psychology, Bar Ilan University, Ramat Gan, Israel. weller@mail.biu.ac.il

Developmental Psychobiology
|August 11, 2000
PubMed
Summary
This summary is machine-generated.

Cholecystokinin (CCK) mediates milk-induced quieting of ultrasonic vocalizations (USV) in rat pups. However, CCK is not involved in dam-induced quieting, suggesting multiple pathways for reducing distress.

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Area of Science:

  • Neuroscience
  • Behavioral Biology
  • Developmental Psychology

Background:

  • Separation distress in infant mammals is characterized by ultrasonic vocalizations (USV).
  • Cholecystokinin (CCK) is a neuropeptide implicated in various physiological and behavioral processes, including feeding and stress responses.
  • Previous research suggests CCK may play a role in modulating infant distress behaviors.

Purpose of the Study:

  • To investigate the specific role of cholecystokinin (CCK) in reducing separation-induced ultrasonic vocalizations (USV) in rat pups.
  • To differentiate the effects of CCK on milk-induced versus dam-induced quieting.

Main Methods:

  • 10-11-day-old rat pups were isolated and their USV rates measured.
  • The selective CCK(A) receptor antagonist devazepide was administered peripherally.
  • USV rates were assessed following exposure to milk-scented paper or contact with an anesthetized dam.

Main Results:

  • Devazepide administration blocked the reduction in USV typically observed when pups were exposed to milk.
  • Devazepide did not affect feeding behavior.
  • Devazepide did not alter the quieting effect of contact with the dam on USV.
  • Opiate antagonist naltrexone's effects were also considered in comparison.

Conclusions:

  • Cholecystokinin (CCK) specifically mediates the quieting of ultrasonic vocalizations (USV) induced by milk cues.
  • CCK does not appear to mediate USV reduction caused by the presence of the dam.
  • These findings suggest that CCK is part of a pathway for milk-induced calming, distinct from dam-induced calming, which may involve redundant pathways including opioids.