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Synthesis and biological activity of phenoxyphenyl oxamic acid derivatives related to L-thyronine
J L Stanton1, E Cahill, R Dotson
1Metabolic and Cardiovascular Diseases Research, Novartis Institute for Biomedical Research, Summit, NJ 07901, USA. james.stanton@pharma.novartis.com
Bioorganic & Medicinal Chemistry Letters
|August 11, 2000
Abstract:
The synthesis of substituted phenoxyphenyl oxamic acid derivatives related to L-thyronine (L-T3) is described. The in vitro and in vivo cholesterol lowering and cardiovascular effects of these compounds are presented and discussed.