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Updated: Aug 18, 2026

Rapid Screening of HIV Reverse Transcriptase and Integrase Inhibitors
Published on: April 9, 2014
Synthesis and evaluation of quinoxalinones as HIV-1 reverse transcriptase inhibitors
M Patel1, R J McHugh, B C Cordova
1DuPont Pharmaceuticals Company, Experimental Station, Wilmington, DE 19880-0500, USA. mona.patel@dupontpharma.com
Abstract:
A series of 3,3-disubstituted quinoxalinones was prepared and evaluated as HIV-1 reverse transcriptase inhibitors. The N-allyl (6b and 6f), N-cyclopropylmethyl (6a, 6g, 6h, and 6k) and N-carboalkoxy (6m-6y) substituted compounds displayed activity comparable or better than Efavirenz and GW420867X.
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