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Studies on the novel anti-staphyloccal compound nematophin
G Kennedy1, M Viziano, J A Winders
1Medicines Research Centre, Glaxo Wellcome SpA, Verona, Italy. gk27184@glaxowellcome.co.uk
Bioorganic & Medicinal Chemistry Letters
|August 11, 2000
Abstract:
A number of analogues of the recently described compound nematophin were prepared and studied for antibacterial activity. The 2-phenyl derivative was found to exhibit exceptional activity against methicillin resistant Staphylococcus aureus (MRSA) whereas the isosteric benzimidazole analogue was much less active.