Encephalitozoonosis in laboratory animals--a serological survey

Area of Science:

• Veterinary Parasitology
• Immunology
• Laboratory Animal Science

Background:

• Encephalitozoon cuniculi is an intracellular protozoan parasite.
• Prevalence studies are crucial for managing infections in laboratory animals.

Purpose of the Study:

• To investigate the seroprevalence of Encephalitozoon cuniculi antibodies in various laboratory animal species.
• To identify potential sources and transmission patterns of Encephalitozoon cuniculi in animal colonies.

Main Methods:

• Serum samples from rabbits, guinea pigs, Syrian golden hamsters, and rats were tested.
• Indirect fluorescent antibody test (IFAT) was employed to detect antibodies.
• Animals were sourced from diverse breeding stations and laboratory colonies.

Main Results:

• Antibodies to Encephalitozoon cuniculi were prevalent in rabbits (0-95%), guinea pigs (29-85%), hamsters (14-80%), and rats (15-30%).
• Mice from multiple colonies exhibited no significant positivity for Encephalitozoon cuniculi antibodies.
• Prevalence varied considerably among different colonies within the same species.

Conclusions:

• Encephalitozoon cuniculi infection is widespread in several species of laboratory animals, particularly in rabbits, guinea pigs, hamsters, and rats.
• The high variability in prevalence suggests challenges in controlling and eradicating the parasite.
• Further research is needed to understand the implications of these findings for animal health and experimental research.