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Updated: Oct 13, 2026

Quantification of Autoreactive Antibodies in Mice upon Experimental Autoimmune Encephalomyelitis
Published on: December 1, 2023
Influence of auto-antibody specificities on the clinical course in patients with chronic and acute ITP
Y S Mehta1, A V Pathare, S S Badakere
1Institute of Immunohaematology (ICMR), K.E.M. Hospital Campus, Parel, Mumbai, India. yasheshmehta@hotmail.com
Abstract:
It is now well established that the target antigens of platelet auto-antibodies are the GP IIb/IIIa and GP Ib/IX receptors. In our study, it was observed that the majority of patients had antibodies directed towards the GP IIb/IIIa receptor, whereas the number of patients having antibodies directed towards the GP Ib/IX receptor was much less. Also, we found that the patients in whom the auto-antibodies are directed towards the GP IIb/IIIa receptors usually have mild bleeding. On the other hand, the patients having auto-antibodies directed towards both GP IIb/IIIa and GP Ib/IX receptors have a severe bleeding diathesis, and usually show poor prognosis to treatment with corticosteroids.
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