Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Experiment Videos

DNA vaccines.

J Reimann1, R Schirmbeck

  • 1Institute for Medical Microbiology and Immunology, University of Ulm, Germany.

Vox Sanguinis
|August 12, 2000
PubMed
Summary
This summary is machine-generated.

DNA vaccination efficiently primes humoral and cellular immunity by expressing intact proteins for antibody responses and processed peptides for T cell responses. This approach offers advantages over traditional subunit vaccines.

Related Concept Videos

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Build-up and dephasing of Floquet-Bloch bands on subcycle timescales.

Nature·2023
Same author

Ultrafast electron dynamics in a topological surface state observed in two-dimensional momentum space.

Scientific reports·2023
Same author

TEMPORARY REMOVAL: VP.47 Interleukin 31 (IL-31) inhibition as a trigger for an immune-mediated myopathy?

Neuromuscular disorders : NMD·2022
Same author

Current production by non-methanotrophic bacteria enriched from an anaerobic methane-oxidizing microbial community.

Biofilm·2021
Same author

[Pain management in rare diseases].

Schmerz (Berlin, Germany)·2020
Same author

A 192-heme electron transfer network in the hydrazine dehydrogenase complex.

Science advances·2019
Same journal

Barriers and enablers to non-remunerated plasma donation: A meta-synthesis of the qualitative literature using the theoretical domains framework.

Vox sanguinis·2026
Same journal

Haemolytic disease of the foetus and newborn due to anti-M: A systematic review.

Vox sanguinis·2026
Same journal

In vitro evaluation of apheresis platelet and plasma products collected and stored in non-DEHP disposable sets.

Vox sanguinis·2026
Same journal

Survey of national and regional rare donor programmes regarding Immunoglobulin A deficiency.

Vox sanguinis·2026
Same journal

Fibrinogen recovery in cryoprecipitate prepared from thawed plasma stored for 5 days post-thaw.

Vox sanguinis·2026
Same journal

Abstracts of the 39th International Congress of the ISBT, Kuala Lumpur, Malaysia, 20-24 June 2026.

Vox sanguinis·2026
See all related articles

Area of Science:

  • Immunology
  • Vaccinology
  • Molecular Biology

Background:

  • Nucleic acid (DNA or RNA) vaccination effectively induces immune responses against protein antigens.
  • DNA vaccination ensures proper protein expression, post-translational modification, and conformation, crucial for epitope integrity and neutralizing antibody generation.
  • It excels at stimulating T cell responses due to efficient endogenous or exogenous antigen processing pathways.

Purpose of the Study:

  • To review the current state of DNA vaccine technology.
  • To discuss vector designs, delivery strategies, and immune response priming.
  • To highlight the advantages, experimental applications, and clinical/preclinical experiences with DNA vaccination.

Main Methods:

  • Review of existing literature on DNA vaccination.

Related Experiment Videos

  • Discussion of vector design and delivery systems.
  • Analysis of preclinical and clinical trial data.

    • Main Results:

    • DNA vaccination demonstrates potent induction of both humoral (B cell) and cellular (T cell) immunity.
    • It overcomes limitations of recombinant subunit vaccines regarding protein integrity and antigen processing.
    • Successful application in preclinical models and ongoing clinical trials.

    Conclusions:

    • DNA vaccination is a powerful tool for generating robust immune responses.
    • Its ability to ensure antigen integrity and efficient T cell priming offers significant advantages.
    • Further research and clinical development are warranted to explore its full potential and risks.