Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Experiment Videos

Hepatitis C lookback in Canada.

M Goldman1, A Long

  • 1mgoldman@hema-quebec.qc.ca

Vox Sanguinis
|August 12, 2000
PubMed
Summary
This summary is machine-generated.

Hepatitis C virus (HCV) lookback studies in Canada identified a 19% link between blood components and anti-HCV positive recipients. General notification found approximately twice the general population

Related Concept Videos

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Genetic risk-targeted islet autoantibody screening for presymptomatic type 1 diabetes in adults.

The lancet. Diabetes & endocrinology·2025
Same author

Multi-criteria analysis of strategies towards sustainable recycling of phosphorus from sewage sludge in Austria.

Journal of environmental management·2024
Same author

Exploring management and outcomes of elderly patients with glioblastoma using data from two randomised trials (GEINO1401/EX-TEM).

Journal of neuro-oncology·2024
Same author

Correction to: A combined analysis of two prospective randomised studies exploring the impact of extended post-radiation temozolomide on survival outcomes in newly diagnosed glioblastoma.

Journal of neuro-oncology·2024
Same author

A combined analysis of two prospective randomised studies exploring the impact of extended post-radiation temozolomide on survival outcomes in newly diagnosed glioblastoma.

Journal of neuro-oncology·2023
Same author

Proposal of the French Society of Vascular Medicine for the prevention, diagnosis and treatment of venous thromboembolic disease in outpatients with COVID-19.

Journal de medecine vasculaire·2020
Same journal

Barriers and enablers to non-remunerated plasma donation: A meta-synthesis of the qualitative literature using the theoretical domains framework.

Vox sanguinis·2026
Same journal

Haemolytic disease of the foetus and newborn due to anti-M: A systematic review.

Vox sanguinis·2026
Same journal

In vitro evaluation of apheresis platelet and plasma products collected and stored in non-DEHP disposable sets.

Vox sanguinis·2026
Same journal

Survey of national and regional rare donor programmes regarding Immunoglobulin A deficiency.

Vox sanguinis·2026
Same journal

Fibrinogen recovery in cryoprecipitate prepared from thawed plasma stored for 5 days post-thaw.

Vox sanguinis·2026
Same journal

Abstracts of the 39th International Congress of the ISBT, Kuala Lumpur, Malaysia, 20-24 June 2026.

Vox sanguinis·2026
See all related articles

Area of Science:

  • Hepatology
  • Infectious Diseases
  • Public Health

Background:

  • Canadian blood donations screened for Hepatitis C Virus (HCV) antibodies since 1990 using EIA and RIBA.
  • Targeted HCV lookback studies initiated in 1995 for confirmed positive donations.
  • General lookback implemented in provinces following public inquiry recommendations.

Purpose of the Study:

  • Evaluate the effectiveness of targeted and general HCV lookback strategies in Canada.
  • Determine the rate of anti-HCV positive recipients among those transfused prior to widespread HCV testing.
  • Assess the resources and challenges associated with blood donor and patient notification.

Main Methods:

  • Targeted lookback on donors confirmed positive by RIBA testing.
  • Re-testing of indeterminate samples and subsequent lookback.

Related Experiment Videos

  • Hospital surveys in Quebec to assess lookback methods and resources.
  • Centralized transfusion data banks and linkage with provincial data for general notification.

    • Main Results:

    • Targeted lookback on 1,628 anti-HCV positive donors linked 19% of components to positive recipients.
    • Of 1,422 recipients tested, 67% were anti-HCV positive; half were already aware.
    • General notification in BC and PEI tested 38,960 and 1,953 recipients, finding 5.0% and 2.2% anti-HCV positive, respectively.
    • Lookback efforts hampered by resource limitations and manual record-keeping.

    Conclusions:

    • Targeted lookback investigations reveal a significant link between blood components and anti-HCV positive recipients.
    • General letter notification identifies anti-HCV positivity at approximately twice the rate of the general population.
    • Results align with international findings from Denmark and the UK, highlighting the importance of lookback programs.