Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Experiment Videos

Immunomodulation by blood transfusions.

D L Roelen1, J J van Rood, A Brand

  • 1Leiden University Medical Center, Dept. Immunohaematology and Blood Transfusion, The Netherlands.

Vox Sanguinis
|August 12, 2000
PubMed
Summary
This summary is machine-generated.

Related Concept Videos

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Value of Routine Pelvic Examination in the Follow-Up of Patients Receiving Adjuvant Radiation Therapy for Endometrial Cancer: An Australian Tertiary-Centre Experience.

Journal of medical imaging and radiation oncology·2025
Same author

Epithelial RANKL Limits Experimental Periodontitis via Langerhans Cells.

Journal of dental research·2024
Same author

Medical graphics to improve patient understanding and anxiety in elderly and cognitively impaired patients scheduled for transcatheter aortic valve implantation (TAVI).

Clinical research in cardiology : official journal of the German Cardiac Society·2023
Same author

Informed Consent before coronary angiography and percutaneous coronary intervention from the patient's perspective: A picture is worth a thousand words.

International journal of cardiology. Heart & vasculature·2022
Same author

Review of indications for immunoglobulin (IG) use: Narrowing the gap between supply and demand.

Transfusion clinique et biologique : journal de la Societe francaise de transfusion sanguine·2020
Same author

A nurse- and peer-led psycho-educational intervention to support women with gynaecological cancers receiving curative radiotherapy: The PeNTAGOn randomised controlled trial - ANZGOG 1102.

Gynecologic oncology·2020
Same journal

Red cell alloantibodies in 71,525 Malaysian blood donations: Predominance of anti-Mia reflects GP.Mur-associated antigenic diversity.

Vox sanguinis·2026
Same journal

Barriers and enablers to non-remunerated plasma donation: A meta-synthesis of the qualitative literature using the theoretical domains framework.

Vox sanguinis·2026
Same journal

Haemolytic disease of the foetus and newborn due to anti-M: A systematic review.

Vox sanguinis·2026
Same journal

In vitro evaluation of apheresis platelet and plasma products collected and stored in non-DEHP disposable sets.

Vox sanguinis·2026
Same journal

Survey of national and regional rare donor programmes regarding Immunoglobulin A deficiency.

Vox sanguinis·2026
Same journal

Fibrinogen recovery in cryoprecipitate prepared from thawed plasma stored for 5 days post-thaw.

Vox sanguinis·2026
See all related articles

Blood transfusions can induce either immune tolerance or immunization. HLA-DR compatibility in transfusions promotes tolerance, potentially via CD4+ regulatory T cells, which may downregulate alloimmune responses.

Area of Science:

  • Immunology
  • Transfusion Medicine
  • Transplantation

Background:

  • Blood transfusions can paradoxically induce immune tolerance or immunization.
  • Immunization involves HLA alloantibody induction and T cell activation.
  • Tolerance is suggested by improved graft survival in transfused recipients.

Purpose of the Study:

  • To investigate the immunological mechanisms behind transfusion-induced immune tolerance.
  • To explore the role of HLA compatibility in modulating alloimmune responses.
  • To test the hypothesis that CD4+ regulatory T cells mediate tolerance.

Main Methods:

  • Analysis of HLA compatibility between transfusion donors and recipients.
  • Investigating the role of Th2 responses and non-professional antigen presentation.

Related Experiment Videos

  • Identifying CD4+ T cells specific for allopeptides in the context of self-HLA-DR.

    • Main Results:

    • Transfusions sharing HLA-DR antigens induce tolerance, while mismatched transfusions lead to immunization.
    • Preliminary data show CD4+ T cells recognizing allopeptides in self-HLA-DR context can downregulate alloimmune responses.
    • Evidence suggests a central role for CD4+ regulatory T cells in tolerance induction.

    Conclusions:

    • HLA-DR compatibility is a key factor in transfusion outcomes.
    • CD4+ regulatory T cells recognizing allopeptides in a self-HLA-DR context may be responsible for tolerance.
    • Further studies on transplant patients are needed to confirm the role of these regulatory T cells.