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Related Experiment Videos

RNA structure. Ribozyme evolution at the crossroads.

G F Joyce1

  • 1Department of Chemistry, Skaggs Institute for Chemical Biology, The Scripps Research Institute, La Jolla, CA 92037, USA. gjoyce@scripps.edu

Science (New York, N.Y.)
|August 12, 2000
PubMed
Summary
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Similar RNA sequences typically have identical structures and functions. However, a new study shows an RNA molecule can adopt two distinct structures, each with a unique catalytic function, offering insights into enzyme evolution.

Area of Science:

  • Biochemistry
  • Molecular Biology
  • Enzyme Evolution

Background:

  • Traditionally, similar molecular sequences are presumed to yield identical structures and functions.
  • This principle has guided research in molecular biology and biochemistry for decades.

Discussion:

  • A recent study by Schultes and Bartel challenges this assumption by designing a novel RNA sequence.
  • This engineered RNA molecule demonstrates the capacity to fold into two distinct three-dimensional structures.
  • Each of these RNA structures exhibits a different catalytic activity, a significant departure from conventional understanding.

Key Insights:

  • The research highlights that sequence-structure-function relationships in RNA are more complex than previously thought.
  • This finding has profound implications for understanding the potential diversity of molecular functions within biological systems.
Keywords:
NASA Discipline ExobiologyNon-NASA Center

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  • It suggests a broader scope for molecular evolution than currently appreciated.

    • Outlook:

    • This work provides a new perspective on the evolution of enzymes, particularly the emergence of catalytic diversity.
    • Further research could explore the mechanisms underlying such structural plasticity in RNA and other biomolecules.
    • The study opens avenues for designing novel RNA-based catalysts with multiple functions.