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Updated: Aug 2, 2026
07:09
Experimental and Imaging Techniques for Examining Fibrin Clot Structures in Normal and Diseased States
Published on: April 1, 2015
A beta fibrillogenesis: kinetic parameters for fibril formation from congo red binding
1Department of Biology, Boston College, Chestnut Hill, Massachusetts, 02467-3811, USA.
Journal of Structural Biology
|August 15, 2000
Abstract:
Using Scatchard analysis, we have formulated as a function of time and pH the relationship between the binding of Congo red to Alzheimer's beta-amyloid and the aggregation number (i.e., monomer concentration within fibrils) as defined by nucleation-dependent self-assembly. This provides a basis on which to determine the kinetic parameters for fibril formation from the observed concentration of bound Congo red.
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