Chromatographic hydrophobic parameters in correlation analysis of structure-activity relationships

The use of RM and delta RM parameters as indices of hydrophobicity for inclusion in quantitative structure activity relationships has been studied. The relationship between these parameters and other free-energy related parameters is illustrated theoretically and experimentally. It is suggested that the chromatographically obtained parameters could find a wider applicability in structure-activity relationships, and that their use would result in improved correlation of data.