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Selamectin: a novel broad-spectrum endectocide for dogs and cats
B F Bishop1, C I Bruce, N A Evans
1Animal Health Discovery, Central Research Division, Pfizer Limited, Sandwich, Kent, UK. bernard-bishop@sandwich.pfizer.com
Veterinary Parasitology
|August 15, 2000
Summary
Selamectin is a new drug effective against fleas, ticks, and common intestinal parasites in dogs and cats. It is also safe for Collies, a breed sensitive to similar avermectin drugs.
Area of Science:
- Veterinary Pharmacology
- Parasitology
Background:
- Avermectins are widely used antiparasitic drugs.
- Some breeds, like Collies, exhibit sensitivity to avermectins.
- Novel endectocides with improved safety profiles are needed.
Purpose of the Study:
- To evaluate the efficacy and safety of selamectin in dogs and cats.
- To assess selamectin's tolerability in Collies.
Main Methods:
- Oral and topical administration of selamectin.
- Efficacy testing against fleas, ticks, hookworms, ascarids, and immature heartworms.
- Dosage-ranging safety studies in Collies.
Main Results:
- Selamectin demonstrated efficacy against a broad spectrum of parasites.
- The compound was well-tolerated following both administration routes.
- Collies tolerated higher selamectin dosages compared to other avermectins.
Conclusions:
- Selamectin is a novel endectocide with a favorable efficacy and safety profile for dogs and cats.
- Its safety in avermectin-sensitive breeds like Collies is a significant advantage.
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