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Updated: Aug 10, 2026

Generation of Human CD40-activated B cells
Published on: October 17, 2009
Immunological function of tubular epithelial cells: the functional implications of CD40 expression
C van Kooten1, A M Woltman, M R Daha
1Department of Nephrology, Leiden University Medical Center, Leiden, The Netherlands.Kooten@mail.Medfac.LeidenUniv.nl
Abstract:
Tubulo-interstitial inflammation in the kidney is characterized by the presence of activated T cells. Both by the local production of cytokines, as well as by direct cell-cell interactions, these activated T cells might affect the immune and inflammatory response. Recently it has been demonstrated that these kidney-infiltrating T cells express CD40 ligand and that tubular epithelial cells (TECs) express CD40. In the present review we will discuss the potential implications of CD40-CD40L interactions for the activation of TECs and its immunological function.
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