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Maintenance of IL-12-responsive CD4+ T cells during a Th2 response in Leishmania major-infected mice

B D Hondowicz1, A Y Park, M M Elloso

  • 1University of Pennsylvania, School of Veterinary Medicine, Philadelphia 19104, USA.

European Journal of Immunology
|August 15, 2000
PubMed

BALB/c and anti-IL-12-treated C3H mice infected with Leishmania major develop a Th2 cell response. However, in contrast to BALB/c mice, C3H mice treated transiently with an anti-IL-12 monoclonal antibody switch from a Th2 to a Th1 response and resolve their lesions once treatment is terminated. We report here that the critical difference in the Th2 response between BALB/c and C3H mice is in their ability to respond to IL-12. Thus, C3H mice with a Th2 response maintain a CD4+ T cell population that expresses IL-12 receptor beta1 and beta2 mRNA and produces IFN-gamma after exposure to IL-12. These results indicate that Th2 cell populations from different genetic backgrounds differ in their stability, and that this difference can be related to differential regulation of the IL-12 receptor.

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