[Towards a consensus regarding androgen substitution therapy for andropause]

Area of Science:

• Andrology
• Endocrinology
• Gerontology

Context:

• Andropause, or male climacteric, is compared to female menopause.
• Testosterone decline varies significantly among men, influenced by genetics and lifestyle factors like stress, obesity, and inactivity.
• This decline can begin as early as the 40s or occur much later.

Purpose:

• To explore the concept of andropause and its underlying mechanisms.
• To highlight the symptoms and consequences of testosterone deficiency in aging men.
• To discuss the rationale and considerations for treating androgen deficiency.

Summary:

• Male gonadal function decline (andropause) is highly individualized, unlike female menopause.
• Symptoms include sexual dysfunction, reduced libido, and reversible changes in lipid profile, muscle mass, bone density, and psychological parameters.
• Treatment for androgen deficiency is recommended after a urological evaluation, with administration methods tailored to patient goals.

Impact:

• Provides a comprehensive overview of andropause, differentiating it from female menopause.
• Emphasizes the multifactorial nature of testosterone decline and its broad physiological effects.
• Recommends a proactive approach to managing androgen deficiency in aging men, stressing the importance of medical supervision.