Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Experiment Videos

Umbilical vein as ureteral replacement.

K F Klippel, R Hohenfellner

    Investigative Urology
    |May 1, 1979
    PubMed
    Summary
    This summary is machine-generated.

    Umbilical cord vein grafts show promise for ureter replacement in dogs, with a 60% success rate. This embryonic tissue exhibits low antigenicity, suggesting suitability for transplantation in urologic reconstructive surgery.

    Related Concept Videos

    You might also read

    Related Articles

    Articles linked to this work by shared authors, journal, and citation graph.

    Sort by
    Same author

    [Caudal migration of the verumontanum and enlargement of the utricle in hypospadias].

    Der Urologe. Ausg. A·2014
    Same author

    Xenobiotic metabolizing enzyme activities in isolated and cryopreserved human liver parenchymal cells.

    Toxicology in vitro : an international journal published in association with BIBRA·2010
    Same author

    The semiclosed membership system of the German-Japanese Confederation of Urology.

    Aktuelle Urologie·2010
    Same author

    Nerve injuries in urological surgery.

    Georgian medical news·2007
    Same author

    The Mainz pouch (mixed augmentation ileum 'n zecum) for bladder augmentation and continent urinary diversion. 1985.

    European urology·2006
    Same author

    [100 years urology--surgical techniques].

    Der Urologe. Ausg. A·2006

    Area of Science:

    • Urology
    • Transplantation Biology
    • Biomaterials Science

    Background:

    • Ureteral reconstruction presents challenges due to the ureter's specific anatomical and functional requirements.
    • Biomaterial-based grafts are explored as alternatives for ureteral replacement, aiming to overcome limitations of autografts and synthetic materials.

    Purpose of the Study:

    • To evaluate the efficacy and biocompatibility of fresh Rhesus monkey or human umbilical cord vein as a substitute for canine ureteral segments.
    • To assess the long-term histological changes and functional outcomes of umbilical cord vein grafts in a canine model.

    Main Methods:

    • Ureteral segments in 17 dogs were replaced with fresh umbilical cord vein grafts (Rhesus monkey or human).
    • Grafts involved either the middle one-third or the entire ureter.

    Related Experiment Videos

  • Post-operative assessment included intravenous pyelography, radiographic evaluation of kidneys, and long-term histological analysis.

    • Main Results:

    • An overall success rate of 60% (10/17 dogs) was achieved.
    • One dog demonstrated an excellent intravenous pyelogram.
    • Histological examination revealed preserved umbilical vein structure with urothelial replacement of endothelium after 2 years, indicating low antigenicity.

    Conclusions:

    • Fresh umbilical cord vein serves as a viable biomaterial for ureteral replacement in dogs.
    • The low antigenicity of umbilical cord vein makes it a promising candidate for transplantation in urologic reconstructive procedures.
    • Long-term studies show structural integrity and successful tissue integration of the grafts.