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Systemic chemotherapy
V M Klimek1, J D Wolchok, P B Chapman
1Department of Medicine, Memorial Sloan-Kettering Cancer Center, New York, New York, USA.
Clinics in Plastic Surgery
|August 15, 2000
Abstract:
The main use of systemic chemotherapy in metastatic melanoma remains palliative. Dacarbazine (dimethyl-1-triazeno imidazole-4-carboxamide [DTIC]) is the standard chemotherapy agent for advanced disease. The combination chemotherapy and biochemotherapy regimens have achieved higher response rates, but have not led to durable remission or improved survival. The field of systemic therapy remains in need of a more effective and less toxic treatment strategy.