Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Experiment Videos

Residual effects of flunitrazepam.

A J Bond, M H Lader

    British Journal of Clinical Pharmacology
    |April 1, 1975
    PubMed
    Summary

    Flunitrazepam effectively induces hypnosis and reduces anxiety. This hypnotic drug causes significant EEG alterations for up to 18 hours and motor impairment for 12 hours in normal subjects.

    Related Concept Videos

    You might also read

    Related Articles

    Articles linked to this work by shared authors, journal, and citation graph.

    Sort by
    Same author

    What Future for Protected Areas? Analysing the Mismatch between South Africa's Pre-existing Protected areas System and the Declared vision in Contemporary Conservation Policy.

    Environmental management·2024
    Same author

    Physiological and psychological effects of ±-propranolol, +-propranolol and diazepam in induced anxiety.

    British journal of clinical pharmacology·2012
    Same author

    Physiological response to propranolol and diazepam in chronic anxiety.

    British journal of clinical pharmacology·2012
    Same author

    Effect of rate of substitution of processed, urea-treated whole-crop wheat for grass silage on the intake, milk production and diet digestibility in dairy cows and ruminal metabolism in vitro.

    Animal : an international journal of animal bioscience·2012
    Same author

    Commentary on 'Flumazenil-precipitated panic and dysphoria in patients dependent on benzodiazpines: a possible aid to abstinence'.

    Journal of psychopharmacology (Oxford, England)·2012
    Same author

    Central benzodiazepine receptor imaging and quantitation with single photon emission computerised tomography: SPECT.

    Journal of psychopharmacology (Oxford, England)·2012

    Area of Science:

    • Pharmacology
    • Neuroscience
    • Psychology

    Background:

    • Flunitrazepam is a potent hypnotic and anxiolytic benzodiazepine.
    • Understanding its residual effects on cognitive and physiological functions is crucial.

    Purpose of the Study:

    • To evaluate the duration and extent of psychological and physiological effects of flunitrazepam.
    • To assess dose-dependency of flunitrazepam's effects.

    Main Methods:

    • Twelve healthy subjects received hypnotic doses of flunitrazepam (1 or 2 mg) or placebo.
    • A comprehensive battery of psychological and physiological tests were administered at various time points post-drug.

    Main Results:

    • Flunitrazepam demonstrated effective hypnotic and anxiolytic properties.
    • Significant electroencephalogram (EEG) alterations persisted up to 18 hours post-administration.
    • Motor impairment was observed at 12 hours, with dose-related trends noted for most changes.

    Conclusions:

    • Flunitrazepam exerts prolonged effects on EEG and motor function.
    • Residual effects necessitate careful consideration in clinical settings.
    • Observed effects were dose-dependent, highlighting the importance of accurate dosing.

    Related Experiment Videos