Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Experiment Videos

Programmed cell death regulation: basic mechanisms and therapeutic opportunities.

D E Johnson1

  • 1Department of Medicine, University of Pittsburgh, and the University of Pittsburgh Cancer Institute, PA 15213-2582, USA.

Leukemia
|August 15, 2000
PubMed
Summary

Researchers are exploring how cells decide to live or die by studying apoptosis signaling pathways and regulatory proteins. This research aims to understand programmed cell death mechanisms for potential cancer therapies.

Related Concept Videos

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

The health of children adopted from Romania.

JAMA·1992
Same author

Workers' comp: more confusion over dispute resolution.

Texas medicine·1992
Same author

Epididymo-orchitis developing as a late manifestation of intravesical bacillus Calmette-Guerin therapy and masquerading as a primary testicular malignancy: a report of 2 cases.

The Journal of urology·1992
Same author

Maintenance energy requirement of llamas.

American journal of veterinary research·1992
Same author

Histopathologic and angiographic analysis of coronary artery morphology six months after triple artery angioplasty.

The American journal of cardiology·1992
Same author

Iron deficiency of liver, heart, and brain in newborn infants of diabetic mothers.

The Journal of pediatrics·1992

Area of Science:

  • Molecular Biology
  • Cell Biology
  • Biochemistry

Background:

  • Apoptosis (programmed cell death) is a critical cellular process.
  • Understanding apoptosis signaling is key to many diseases, including cancer.
  • Recent advances have shed light on the complex regulatory networks governing apoptosis.

Purpose of the Study:

  • To review the current understanding of apoptosis signaling pathways.
  • To discuss the roles of apoptosis regulatory proteins.
  • To highlight therapeutic opportunities based on apoptosis regulation.

Main Methods:

  • Review of recent mechanistic studies on apoptosis.
  • Analysis of structural data for apoptosis regulatory proteins.
  • Synthesis of information presented at the AACR Special Conference on Programmed Cell Death.

Related Experiment Videos

Main Results:

  • Significant progress has been made in elucidating apoptosis pathways.
  • Key regulatory proteins involved in cell death decisions have been identified.
  • Insights into these pathways offer potential for novel cancer treatments.

Conclusions:

  • The molecular mechanisms of apoptosis are increasingly understood.
  • Apoptosis regulatory proteins are crucial targets for therapeutic intervention.
  • Further research holds promise for developing new cancer therapies targeting cell death.