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Related Experiment Videos

Fetal response to maternally administered morphine.

E A Kopecky1, M L Ryan, J F Barrett

  • 1Division of Clinical Pharmacology and Toxicology, The Hospital for Sick Children, Toronto, Ontario, Canada.

American Journal of Obstetrics and Gynecology
|August 15, 2000
PubMed
Summary

Maternal morphine administration significantly lowers fetal biophysical profile scores, primarily due to absent fetal breathing. This suggests morphine acts as a vasoconstrictor, impacting placental vasculature and fetal well-being.

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Area of Science:

  • Obstetrics and Gynecology
  • Fetal Medicine
  • Pharmacology

Background:

  • Maternal medication use during pregnancy can impact fetal development and well-being.
  • Morphine is an opioid analgesic with potential effects on the fetus.
  • Understanding the fetal response to maternally administered morphine is crucial for clinical practice.

Purpose of the Study:

  • To investigate the effects of maternally administered morphine on fetal response.
  • To assess changes in fetal biophysical parameters and umbilical artery Doppler indices following maternal morphine administration.

Main Methods:

  • Singleton pregnancies undergoing fetal blood sampling were enrolled.
  • Study patients received intramuscular morphine; control patients did not.

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  • Fetal heart rate, biophysical profile score, and umbilical artery Doppler indices were measured before and after drug administration.

    • Main Results:

    • Maternal morphine significantly decreased the biophysical profile score (P=.001).
    • Absent fetal breathing movements and nonreactive nonstress tests contributed to the lower scores.
    • A significant correlation was found between maternal morphine concentration and Doppler indices.

    Conclusions:

    • Maternal morphine administration leads to a significant reduction in the fetal biophysical profile score.
    • Results suggest morphine causes vasoconstriction of placental vasculature.
    • Intramuscular morphine is not recommended for suppressing fetal movement due to adverse effects.