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[New sequential therapy in the premenopause (author's transl)].

K H Conrad, G Heinen

    Medizinische Klinik
    |March 28, 1975
    PubMed
    Summary

    Sequential therapy with conjugated estrogens (Presomen) and a synthetic gestagen effectively treated dysfunctional uterine bleeding and climacteric syndrome in premenopausal women. The 10-day estrogen and 10-day combined regimen showed optimal results, though contraception is not guaranteed.

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    Area of Science:

    • Gynecology
    • Reproductive Endocrinology
    • Pharmacology

    Background:

    • Dysfunctional uterine bleeding (DUB) and climacteric syndrome are common in premenopausal women.
    • Hormonal therapy is a primary treatment modality for these conditions.

    Purpose of the Study:

    • To evaluate the efficacy of sequential therapy with conjugated estrogens (Presomen) and a novel synthetic gestagen in managing DUB and climacteric syndrome.
    • To determine the optimal regimen for this sequential hormonal therapy.

    Main Methods:

    • A study involving 85 premenopausal women over 387 cycles.
    • Sequential administration of conjugated estrogens (Presomen) from day 5 to 24, with varying durations (5, 7, or 10 days) of a synthetic gestagen added.
    • Three different gestagen dosages and durations were tested.
    Keywords:
    Clinical ResearchMenopauseOral Contraceptives, PhasicReproductionResearch Methodology

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    Main Results:

    • Both dysfunctional uterine hemorrhages and the climacteric syndrome showed favorable responses to the sequential therapy.
    • The regimen involving 10 days of estrogens alone followed by 10 days of combined estrogen and gestagen (10+10 mode) yielded the best outcomes.
    • Contraceptive security was not definitively established, indicated by biphasic basal body temperature curves.

    Conclusions:

    • Sequential therapy with conjugated estrogens (Presomen) and a synthetic gestagen is effective for treating DUB and climacteric syndrome in premenopausal women.
    • The 10+10 day regimen (estrogen alone + combined estrogen-gestagen) is the most effective treatment protocol.
    • This hormonal therapy does not provide guaranteed contraception.