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Disseminated intravascular coagulation and purpura fulminans secondary to infection

S N Faust1, R S Heyderman, M Levin

  • 1Department of Paediatrics, Imperial College School of Medicine at St Mary's, Norfolk Place, London, W2 1PG, UK.

Bailliere'S Best Practice & Research. Clinical Haematology
|August 16, 2000
PubMed

Insights

Infection frequently triggers disseminated intravascular coagulation (DIC), a complex blood clotting disorder. This chapter details DIC's cellular and molecular basis and explores current and novel treatment strategies.

Area of Science:

  • Hematology
  • Pathophysiology
  • Infectious Disease

Background:

  • Disseminated intravascular coagulation (DIC) is a critical condition often initiated by infections.
  • It arises from dysregulation of the body's blood clotting mechanisms.
  • Understanding these imbalances is key to managing DIC.

Purpose of the Study:

  • To elucidate the cellular and molecular underpinnings of infection-induced DIC.
  • To review established and emerging therapeutic approaches for DIC.
  • To provide a comprehensive overview for researchers and clinicians.

Main Methods:

  • Review of existing literature on DIC pathogenesis.
  • Analysis of cellular signaling pathways involved in coagulation.
  • Examination of molecular targets for therapeutic intervention.

Main Results:

  • Infections disrupt the balance between procoagulant and anticoagulant factors.
  • Specific cellular mediators and molecular pathways are identified as crucial in DIC development.
  • Current treatments aim to manage the underlying infection and coagulation abnormalities.

Conclusions:

  • Infection-triggered DIC is a complex pathophysiological process.
  • Targeting specific cellular and molecular pathways offers potential for improved DIC management.
  • Further research into experimental therapies is warranted.

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