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Cell delivery to the central nervous system.

M S Shoichet¹, S R Winn

¹Department of Chemical Engineering and Applied Chemistry, Institute of Biomaterials and Biomedical Engineering, University of Toronto, 200 College Street, Toronto, M55 3E5, Ontario, Canada. molly@ecf.utoronto.ca

Advanced Drug Delivery Reviews

|August 16, 2000

Summary

Delivering therapies to the central nervous system (CNS) is challenging due to the blood-brain barrier (BBB). This review explores CNS delivery technologies, focusing on cell transplantation with and without polymer encapsulation.

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Area of Science:

Neuroscience
Biomedical Engineering
Drug Delivery Systems

Background:

Neurological disorders and diseases cause central nervous system (CNS) dysfunction, presenting significant healthcare challenges.
The blood-brain barrier (BBB) severely restricts the delivery of therapeutic molecules to the CNS.
Developing effective CNS therapies requires overcoming the BBB.

Purpose of the Study:

To review current technologies for delivering therapeutic molecules to the CNS.
To emphasize cell transplantation strategies for CNS delivery.
To discuss the role of polymer encapsulation in cell-based CNS therapies.

Main Methods:

Overview of various CNS delivery technologies, including pumps and osmotic BBB opening.
Detailed examination of cell delivery methods for CNS treatment.

Related Experiment Videos

Exploration of polymer encapsulation techniques for enhanced cell delivery.

Main Results:

Cell transplantation shows promise as a strategy for CNS drug delivery.
Polymer encapsulation can improve the efficacy and safety of cell-based CNS therapies.
Various methods exist to bypass or manage the BBB for therapeutic interventions.

Conclusions:

Effective CNS drug delivery remains a critical area for therapeutic development.
Cell transplantation, particularly with polymer encapsulation, offers a viable approach to overcome BBB limitations.
Continued innovation in CNS delivery technologies is essential for treating neurological disorders.